2018年03月

1.Cpf1とシチジンデアミナーゼの融合による1塩基編集 (BE)[出典] "Base editing with a Cpf1–cytidine deaminase fusion" Li X, ~ Huang X, Yang L, Chen J. Nat Biotechnol. Published online 2018 Mar 19.CRISPR-Cas9をベースとするBEの標的はG/CリッチなPAMの制限を ... もっと読む

出典[Resource] "A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors" Venkataraman A, ~ Blackshaw S. Nat Methods 2018 March 19. (bioRxiv Posted March 14, 2017)背景低品質な抗体の利用が生物医学研究に再現性の危機 (repro ... もっと読む

出典[NEWS AND VIEWS]"A new era of rationally designed antipsychotics" Sibley DR, Shi L. Nature. 2018 Mar 8;555(7695):170-172;[論文] "Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone" Wang S, Che T, Levit A, Shoi ... もっと読む

1.CRISPR RNA (crRNA)結合によるCpf1のコンフォメーション変化は、微生物種によって大きく異なる[出典] "Structural insights into the apo-structure of Cpf1 protein from Francisella novicida" Min K, ~ Kim JS, Lee HH. Biochem Biophys Res Commun. 2018 Mar 12. ソ ... もっと読む

1. Salk研報告 (Cas13d;CasRx)[出典] "Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors" Konermann S, Lotfy P, Brideau NJ, Oki J, Shokhirev MN, Hsu PD. Cell. March 15, 2018. Accepted 2018/02/14;Received in revised form 2018/01/31;Rec ... もっと読む

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