2018年06月

1.CRISPR-Cas9遺伝子ドライブに対する耐性発生とその回避法[出典] "Consequences of resistance evolution in a Cas9-based sex-conversion suppression gene drive for insect pest management" KaramiNejadRanjbar M, Eckermann KN, Ahmed HMM, Sánchez C HM, Dippel S, ... もっと読む

1.機能喪失 (LOF)実験の3手法、RNAi、架橋型核酸 (LNA)およびCRISPRi (dCas9–KRAB)、のオフターゲット編集を比較評価[出典] "Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis" Stojic L, Lun ATL et al. Nucleic Acids ... もっと読む

出典"Programming self-organizing multicellular structures with synthetic cell-cell signaling" Toda S (戸田 聡), Blauch LR, Tang SKY, Morsut L, Lim WA. Science 2018 May 31.背景本論文の責任著者のW. A. Lim (UCSF)とL. Morsut (Lim研、現USC)はUCSF研究チームの20 ... もっと読む

1.DNA修復テンプレートをCas9に共有結合させておくと、HDRが亢進する1-1.ETH Zurich/U. Zurich グループ[出典] "Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair" Savic N [..] Schwank G. eLife 2018 May 2 ... もっと読む

出典[論文]"Photosynthetic artificial organelles sustain and control ATP-dependent reactions in a protocellular system" Lee KY [..] Jung KH, Ahn TK, Parker KK, Shin K. Nat Biotechnol 2018 May 28.[NEWS]"A photosynthetic engine for artificial cells" Burrows ... もっと読む

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