2018年08月

[出典]"Humans as models of human disease" Kiberstis PA. Science. 2018 Aug 24;361(6404):763-764;"Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation" Cuchet-Lourenço D, Eletto D, Wu C [..] Nejentsev S ... もっと読む

1. Cas9が誘導するDSBの修復過程で生成される変異は、周囲の配列から予測可能[出典] [bioRxiv版] "Mutations generated by repair of Cas9-induced double strand breaks are predictable from surrounding sequence" Allen F, Crepaldi L [..] Parts L. bioRxiv. 2018 Aug 2 ... もっと読む

1. CRISPR/Cas9を介したproximity ligation assay (CasPLA)法を開発し、ミトコンドリアDNAにおけるSNVを可視化[出典]"Direct Visualization of Single-Nucleotide Variation in mtDNA using a CRISPR/Cas9-Mediated Proximity Ligation Assay (CasPLA)" Zhang K, Deng R, Ten ... もっと読む

[出典] "Cryo-EM structures of the human volume-regulated anion channel LRRC8" Kasuya G, Nakane T, Yokoyama T [..] Ishitani R, Nureki. Nat Struct Mol Biol. 2018 Aug 20 (bioRxiv 2018-5-25):EMD-6952/5ZSU: Structure of the human homo-hexameric LRRC8A chann ... もっと読む

1. ヒト胚ゲノムにおいてBE3によりβ-サラセミア変異を修復 (2017年論文)[出典]"Correction of β-thalassemia mutant by base editor in human embryos" Liang P [..] Songyang Z, Zhou C, Huang J. Protein Cell. 2017 Nov;8(11):811-822. Online 2017 Sep 23.[crisp_bio注 ... もっと読む

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