2018年08月

[出典]"Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector" Cideciyan AV [..] Beltran WA. Proc Natl Acad Sci USA. 2018 AUg 20.背景遺伝性網膜変性症は、視細胞または網膜色素上皮細胞に影響する250種類を超える遺伝子 ... もっと読む

[出典] "Statement on modernizing human gene therapy oversight" The NIH DIRECTOR.NIH 2018 Aug 16;[Perspective]The Next Phase of Human Gene-Therapy Oversight. Collins FS (NIH), Gottlieb S (FDA). N Engl J Med. 2018 Aug 15;"National Institutes of Health (NI ... もっと読む

1. Cas9遺伝子はCampylobacter jejuniの病原性に関与する[出典]"The Involvement of the Cas9 Gene in Virulence of Campylobacter jejuni" Shabbir MAB [..] Yuan Z, Hao H. Front Cell Infect Microbiol. 2018 Aug 20.C. jejuniは胃腸炎の主たる病原菌と見られているが、そ ... もっと読む

[出典]"Conditional control of fluorescent protein degradation by an auxin-dependent nanobody" Daniel K, Icha J, Horenburg C, Müller D, Norden C, Mansfeld J. Nat Commun. 2018 Aug 17. 背景と概要植物に見られるオーキシン依存性タンパク質分解システムを移植す ... もっと読む

1. 塩基編集法BE3によりマルファン症候群(MFS)の病因FBN1変異をヘテロ接合型胚において修復(ヒト胚ゲノム編集)[出典]"Correction of the Marfan Syndrome pathogenic FBN1 mutation by base editing in human cells and heterozygous embryos" Zeng Y [..] Liu J, Huang X. M ... もっと読む

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