2018年10月

[出典] 論文"Programmed DNA destruction by miniature CRISPR-Cas14 enzymes" Harrington LB, Burstein D [..] Doudna JA. Science 2018 Oct 18.;ニュース "Smallest life forms have smallest working CRISPR system" Sanders R. Berkeley News. 2018 Oct 18.要約共生アー ... もっと読む

1. 標的療法と免疫チェックポイント阻害療法の併用による相乗効果[出典] "CRISPR/Cas9 mediated HPV and PD1 inhibition produces a synergistic anti-tumor effect on cervical cancer" Zhen S, Lu J, Hua L, Liu YH, Chen W, Li X. Arch Biochem Biophys. 2018 Oct 10.癌 ... もっと読む

[出典] "Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers" Ding Y [..] Wood KC, Wang XF. Nat Commun. 2018 Oct 15. 乳癌に対するHER2標的療法はHER2陽性乳癌患者の全生存期間を顕著に伸ばすが、ハイリスク ... もっと読む

[出典] "CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response" Szlachta K, Kuscu C, Tufan T [..] Adli M. Nat Commun. 2018 Oct 15.膵癌 (pancreatic ductal adenocarcinoma, PDAC)の患者の93%にKR ... もっと読む

[出典] "Tracing the transitions from pluripotency to germ cell fate with CRISPR screening" Hackett JA, Huang Y, Günesdogan U, Gretarsson KA, Kobayashi T, Surani MA. Nat Commun. 2018 Oct 10.2014年のクリスマス・イヴの日にCell誌オンライン で、ヒトの多能性幹 ... もっと読む

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