2018年12月

[出典] "Synthetic Oligonucleotides Inhibit CRISPR-Cpf1-Mediated Genome Editing" Li B, Zeng C, Li W [..] Zhao W, Zhang C, Dong Y. Cell Rep. 2018-12-18.CRISPR-Casシステムによるゲノム編集を、低分子、温度あるいは光による制御する試みに加えて、最近、抗CRISPR(Ac ... もっと読む

[出典] "Coupled single-cell CRISPR screening and epigenomic profiling reveals causal gene regulatory networks" Rubin AJ [..] Chang HY, Khavari PA. Cell. 2018-12-20. (bioRxiv. 2018-09-13)Stanford University School of Medicine - Program in Epithelial Biolog ... もっと読む

[出典] "Multiplexed orthogonal genome editing and transcriptional activation by Cas12a" Breinig M [..] Tschaharganeh DF. Nat Methods. 2018-12-17.先行研究1[出典] Cas9による遺伝子編集・転写活性化・転写抑制:"Cas9 gRNA engineering for genome editing, activa ... もっと読む

1. [概説]AstraZenecaの創薬戦略[出典] "Improving productivity with better predictivity" Ewart LC, Goodwin RJA, Fawell SE, Hansen PBL, Priestley CC, Rees S, Pangalos MN (AstraZeneca). Drug Discovery World. 2018 Summer.AstraZenecaは、R&Dの新たなフレームワー ... もっと読む

1. [プロトコル] CD4陽性初代T細胞のCRISPR-Cas9ゲノム編集からHIVと宿主因子との相互作用を探る[出典] "CRISPR-Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV-host factor interactions" Hultquist JF [..] Doudna JA, Marson A, Krogan ... もっと読む

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