2019年07月

[出典] "A mutation-independent approach for muscular dystrophy via upregulation of a modifier gene" Kemaladewi DU, Bassi PS [..]  Ivakine EA, Cohn RD. Nature 2019-07-24.背景先天性筋ジストロフィータイプ1A (MDC1A) は、筋線維の安定性や末梢神経のミエリン形 ... もっと読む

[出典] "ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response" Adeyemo AA, Zaghloul NA, [..] Rotimi CN. Nat Commun 2019-07-19. T2Dは国際的に広がっているがこれまでの研究は欧州系に偏っていた。ナイジェリア、 ... もっと読む

1. 冠動脈心疾患のリスク因子LDL-Cのレベルを低減するCRISPR-Cas9システムと送達法[出典] "Triple Targeting Delivery of CRISRP/Cas9 to Reduce the Risk of Cardiovascular Diseases" Zhang L, Wang L, Xie Y [..]  Zheng W, Jiang X. Angew Chem Int Ed Engl. 2019-07-18 ... もっと読む

1.  [プロトコル] i-GONAD[出典] "Creation of CRISPR-based germline-genome-engineered mice without ex vivo handling of zygotes by i-GONAD" Gurumurthy CB [..] Ohtsuka M. Nature Protocol. 2019-07-24.東海大、University of Nebraska Medical Center (UNMC)、鹿児 ... もっと読む

[出典] "Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy" Moreno AN, Palmer N [..] Mali P. Nat Biomed Eng 2019-07-22;"Exploring protein orthogonality in immune space: a case stu ... もっと読む

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