2020年05月

[出典] "Prediction of synonymous corrections by the BE-FF computational tool expands the targeting scope of base editing" Rabinowitz R, Abadi S, Almog S, Offen D. Nucleic Acids Res 2020-04-07. 背景塩基エディター, CBEとABE, によって4種類のトランジッション ... もっと読む

1. [NEWS AND VIEWS] Cas13に基づくSHERLOCKを発展させたCARMENをハイライト[出典] NEWS AND VIEWS "CRISPR tool scales up to interrogate a huge line-up of viral suspects" Storch GA. Nature 2020-05-18. [対象論文と紹介記事] "Massively multiplexed nucleic acid d ... もっと読む

[出典] "Interfering with retrotransposition by two types of CRISPR effectors: Cas12a and Cas13a" Zhang N, Jing X [..] Li X, Hao P. Cell Discov 2020-05-19. 背景と概要CRISPRエフェクターの中で、Cas12aとCas13aはCas9には無い特徴と機能を備えている。例えば、Cas ... もっと読む

[出典] "A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects" Zuo E, Sun Y, Yuan T, He B, Zhou C [..] Li Y, Yang H. Nat Methods 2020-05-18.  Agricultural Genomics Institute at Sh ... もっと読む

[出典] "Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice" Srifa W [..] Porteus M. Nat Commun 2020-05-18.  Stanford University School of Medicineの研究グループは今回、Cas9とsgRNAをRNPまたはRNAとしてエ ... もっと読む

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