[出典] "High‐efficiency genome editing of an extreme thermophile Thermus thermophilus using endogenous type I and type III CRISPR‐Cas systems" Wang J, Wei J, Li H, Li Y. mLife 2022-12-07. https://doi.org/10.1002/mlf2.12045 [著者所属] Huazhong Agric ...
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カテゴリ： CRISPR
ヒトiPS細胞由来心筋細胞において、塩基編集によるエクソンスキッピングを介して、DMDを修正
[注] DMD（Duchenne muscular dystrophy / デュシェンヌ型筋ジストロフィー）[出典] "Correction of DMD in human iPSC-derived cardiomyocytes by base editing-induced exon skipping" Wang P [..] Han R. Mol Ther Methods Clin Dev 2022-11-209 (Accepted). https://doi. ...
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クロマチン修飾を介してCRISPR-Cas9によるHDRを介した編集効率を向上
[注] HDR（homology-directed repair / 相同組換え修復）[出典] "Decorating chromatin for enhanced genome editing using CRISPR-Cas9" Chen E, Lin-Shiao E, Trinidad M [..] Doudna JA. PNAS 2022-12-02. https://doi.org/10.1073/pnas.2204259119 [著者所属] UC Berkele ...
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[レビュー] 免疫細胞療法における多重かつ精密な遺伝子編集
[出典] REVIEW "Multiplexed engineering and precision gene editing in cellular immunotherapy" Biederstädt A, Manzar GS, Daher M. Front Immunol 2022-11-22. https://doi.org/10.3389/fimmu.2022.1063303 [著者所属] The University of Texas MD Anderson Cancer Cen ...
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100万人を超える被験者から冠動脈疾患のリスク変異と関連遺伝子を発見し、系統的に特性を評価
[注] 冠動脈疾患（ coronary artery disease: CAD）[出典] 論文 "Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants" Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS [..] G ...
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