タグ:免疫・療法

[出典] "Critical cancer vulnerabilities identified by unbiased CRISPR/Cas9 screens inform on efficient cancer Immunotherapy" Potts MA, McDonald JA, Sutherland KD, Herold MJ. Eur J Immunol. 2020-11-17. https://doi.org/10.1002/eji.202048712  免疫療法は癌治 ... もっと読む

2020-11-22 更新: FDA, リジェネロン社のCOVID-19の2種類の抗体 (casirivimabとimdevima)のカクテル療法の緊急使用を許可 第1/2/3相試験 (NCT04425629)に由来する軽度から中度で入院していない799名のCOVID-19患者に接種 (内プラセボ 266名)した結果、抗体カクテル療法によ ... もっと読む

[出典] "35 Targeted non-viral integration of large cargo in primary human T cells by CRISPR/Cas9 guided homology mediated end joining" Webber B, Johnson M, Slipek N, et al. Journal for ImmunoTherapy of Cancer 2020-11-09. [Preprint]# 本論文はThe Society f ... もっと読む

[出典] "Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration" Luo B, Zhan Y [..] Zhang Y, Zahng H. Cell Death Dis. 2020-11-12. 長期生存型プラズマ細胞 (Long-lived plasma cells: LLPCs)は主とし ... もっと読む

[出典] "Cutting Edge: CRISPR-Based Transcriptional Regulators Reveal Transcription-Dependent Establishment of Epigenetic Memory of Foxp3 in Regulatory T Cells" Cameron J, Martino P, Nguyen L, Li X. J Immunology. 2020-11-02.  制御性T細胞 (Treg)は、Foxp3 ... もっと読む

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