タグ:免疫・療法

[出典] Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors. Webber BR, Lonetree C [..] Moriarity BS. Nat Commun. 2019-11-19. (bioRxiv. 2018-11-29)概要 University of Minnesotaの研究グループは先行研究 [1 ... もっと読む

[出典] Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity. Wang G, Chow RD [..] Chen S. Nat Immunol. 2019-10-14. Yale University School of Medicineの研究グループは、「AAVによる腫瘍内CRISPRa送達により、腫瘍遺伝子群の発 ... もっと読む

[出典] High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting. Mair B [..] Moffat J, Kelley SO. Nat Biomed Eng. 2019-09-23. (Scalable, FACS-Free Genome-Wide Phenotypic Screening bioRxiv. 2019-04-19); NEWS & VIEWS ... もっと読む

[出典] In vivo CRISPR screening in CD8 T cells with AAV–Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma. Ye L, Park JJ, Dong MB [..] Chen S. Nat Biotechnol. 2019-09-23.  免疫チェックポイントを阻 ... もっと読む

[出典] "Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells" Dong MB, Wang G, Chow RD, Ye L [..] Chen S. Cell 2019-08-22. Yale University School of Medicineの研究グループは今回、トリプルネガティブ乳癌 (TNBC) ... もっと読む

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