タグ:創薬

[出典] "CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML" Vinyard ME [..] Liu BB. Nat Chem Biol. 2019-04-15;"CRISPR-Scanning Towards New Drugs — drug discovery is difficult, but CRISPR might be able to help" Vinyard ME.  Harvard un ... もっと読む

[出典] "Protein-slaying drugs could be the next blockbuster therapies" Scudellari M. Nature. 2019-03-20. PROTACsは、標的タンパク質にユビキチンリガーゼを近接させることで標的タンパク質をユビキチン化し、細胞に内在するユビキチンプロテアソーム系での分解へと誘 ... もっと読む

[出典] NEWS AND VIEWS "Bigger is better in virtual drug screens" Gloriam DE. Nature. 2019-02-06;論文 "Ultra-large library docking for discovering new chemotypes" Lyu J, Wang S, Balius TE, Singh I [..] Shoichet BK, Roth BL, Irwin JJ. Nature. 2019-02-06.  ... もっと読む

出典NEWS & VIEWS "An in-depth structural view of a GABAA brain receptor" Jansen M. Nature. 2019-01-02.論文 "Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer" Laverty D [..] Miller KW, Aricescu AR. Nature. 2019-01-02;EMD-4411/P ... もっと読む

1. セロトニン受容体5-HT2Aと第2世代統合失調症治療薬との複合体構造[出典] "Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine" Terakado Kimura K [..] Iwata S, Shimamura T. Nat Struct Mol Biol. 2019-02-04. (crisp_b ... もっと読む

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