タグ:合成致死

[出典] "Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets" Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ. Mol Cell. 2019-01-24.背景二本鎖DNA切断 (DSB)の修復過程には相同組み換え(HR)、非相同末端結合 ( ... もっと読む

[出典] "Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells" Benjamin D, Robay D [..] Lane HA, Hall MN. Cell Rep. 2018 Dec 11;25(11):3047-3058.e4.概要2型糖尿病治療薬として最も ... もっと読む

ASH Annual Meeting Abstracts (Blood. 2018 132 Spplement 1)から CRISPR/Cas9によるダウン症患者における急性白血病のモデリング - GATA1変異のモデリング:Modeling the Initiation and Evolution of Down Syndrome Associated Leukemia Using CRISPR/Cas9. Wagenblast E ... もっと読む

1. ナノ磁石を介してin vivo CRISPR-Cas9ゲノム編集の空間的制御を実現[出典] "Spatial control of in vivo CRISPR–Cas9 genome editing via nanomagnets" Zhu H, Zhang L, Tong S, Lee CM, Deshmukh H, Bao G (Rice U). Nat Biomed Eng. 2018-11-12:News & Views "Local ... もっと読む

[出典] "Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers" Ding Y [..] Wood KC, Wang XF. Nat Commun. 2018 Oct 15. 乳癌に対するHER2標的療法はHER2陽性乳癌患者の全生存期間を顕著に伸ばすが、ハイリスク ... もっと読む

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