[出典] "Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome" Parrish PCR, Thomas JD [..] Berger AH. Cell Rep 2021-08-31. https://doi.org/10.1016/j.celrep.2021.109597 [著者所属] Fred Hutchinson Cancer Research Center, U W ...
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タグ:合成致死
がん細胞株におけるパラログペア間のロバストな合成致死の包括的予測
[出典] "Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines" De Kegel B, Ryan CJ. Cell Systems 2021-09-15. https://doi.org/10.1016/j.cels.2021.08.006 [著者所属] U College Dublin, Wellcome Sanger Institute;右 ...
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ゲノムワイドCRISPRスクリーンを介して, 機能喪失しているがん抑制遺伝子を標的とするがん療法の可能性を示した
[出典] "Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors" Feng X, Tang M, Dede M [..] Hart T, Chen J. Sci Adv 2022-05-13. https://doi.org/10.1126/sciadv.abm6638 [著者所属] UTEX MD Anderson Cance ...
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CRISPR-Cas9スクリーンを介してCCNE1増幅腫瘍細胞を合成致死に誘導するPKMYT1キナーゼ阻害剤を同定
[出典] "CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition" Gallo D, Young JTF, Fourtounis J [..] Marshall CG, Durocher D. Nature 2022-04-28. https://doi.org/10.1038/s41586-022-04638-9 [著者所属] Mount Sinai Hospital, Repare Therapeut ...
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CRISPRスクリーニングにより,前立腺がんのPARP阻害剤に対する感受性を増減させる一連の遺伝子を同定
[注] 前立腺がん (prostate cancer: PCa); PARP阻害剤 (PARP inhibitor: PARPi)[出典] "CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer" Tsujino T, Takai T, Hinohara K [..] Jia L. bioRixv 2022-04-14 [プ ...
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