タグ:塩基エディター(BE&PE)

[出典] NEWS "In its first tough test, CRISPR base editing slashes cholesterol levels in monkeys" Begley S STAT 2020-06-27; ICCSR 2020講演者・Verve Therapeutics共同設立者Kiran Musunuruのツイート[文末に引用] ICCRS (国際幹細胞学会) 2020 Virtual Meetingの"C ... もっと読む

[出典] "Designing sgRNAs for CRISPR-BEST base editing applications with CRISPy-web 2.0" Blin K, Shaw S, Tong Y, Weber T. Synth Syst Biotechnol 2020-06-13.  BE3 (rAPOBEC1-Cas9n (D10A)-UGI)をストレプトマイセス属にコドン最適化し、CRISPR-BEST (CRISPR-Base E ... もっと読む

[出典] "Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors" Anzalone AV, Koblan LW, Liu DR. Nat Biotechnol 2020-06-22.  D. R. LiuがTwitterで「本編21ページ、 補足16ページ、文献454編のCRISPR-Cas技術レビュー、今すぐに ... もっと読む

[出典] "Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning" Arbab M [..] Liu DR. Cell 2020-06-12.  標的塩基のトランジッション変異を誘導する塩基エディター (CBEsとABEs)は、短期間で、病因SNV変異の修復を始めとして基礎と ... もっと読む

[出典] "Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response" Wang X, Ding C, Yu W [..] Liu Z, Yang L, Chen J. Cell Rep 2020-06-02 [注] BEACONは、"base editing induced by human APOBEC3A and Cas12a without DNA break"に由 ... もっと読む

↑このページのトップヘ