タグ:癌

[出典] "Critical cancer vulnerabilities identified by unbiased CRISPR/Cas9 screens inform on efficient cancer Immunotherapy" Potts MA, McDonald JA, Sutherland KD, Herold MJ. Eur J Immunol. 2020-11-17. https://doi.org/10.1002/eji.202048712  免疫療法は癌治 ... もっと読む

[出典] "Identification of the HECT E3 ligase UBR5 as a regulator of MYC degradation using a CRISPR/Cas9 screen" Schukur L [..] Reschke M, Radimerski T, Thoma CR. Sci Rep. 2020-11-18. https://doi.org/10.1038/s41598-020-76960-z MYCタンパク質の発現レベル異 ... もっと読む

[出典] "Genome‐scale CRISPR screening identifies cell cycle and protein ubiquitination processes as druggable targets for erlotinib‐resistant lung cancer" Lee J, Choi A, Cho SY [..] Lee S, Charles L. Mol Oncol 2020-11-14.  梨花女子大学校の研究グルー ... もっと読む

[出典] REVIEW "CRISPR-Cas deployment in non-small cell lung cancer for target screening, validations, and discoveries" Sreedurgalakshmi K, Srikar R, Rajkumari R. Cancer Gene Ther 2020-11-15. Vellore Institute of Technology (インド)の研究チームが、NSCLCを ... もっと読む

[出典] "A CRISPR-Cas9 repressor for epigenetic silencing of KRAS" Liu J, Sun M, Cho KB, Gao X, Guo B. Pharmacol Res. 2020-11-14.  University of Houstonの研究グループは今回、KRASのプロモーター領域を標的とするdCas9-HDAC1によるKRAS遺伝子サイレンシングを介 ... もっと読む

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