タグ:CAR-T

[出典] COMMENTARY "CRISPR-Edited Immune Effectors: The End of the Beginning" Mo F, Heslop HE, Mamonkin M (Baylor College of Medicine). Mol Ther. 2020-03-22.  PD-1 (PDCD1)とTCR α/β (TRAC/TRBC遺伝子)の3遺伝子をノックアウトし、NY-ESO-1/LAGE-1特異的TCRを ... もっと読む

1. [レビュー] デュシェンヌ型筋ジストロフィー (DMD)のCRISPR遺伝子治療[出典] REVIEW "CRISPR Correction of Duchenne Muscular Dystrophy" Min YL, Bassel-Duby R, Olson EN (U. Texas Southwestern Medical Center). Annu Rev Med. 2018-10-31.(2019年1月に最終版出版予 ... もっと読む

[出典] "Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell" Ruella M, Xu J, Barrett DM [..] Lacey SF, Melenhorst  JJ. Nat Med. 2018 Oct 1.背景FDAとEPはそれぞれ2017年と2018年に、キメラ抗原受容体 ... もっと読む

出典"Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo&イタ&." Rafiq S, Yeku OO, Jackson HJ, Purdon TJ, van Leeuwen DG, Drakes DJ, Song M, Miele MM, Li Z, Wang P, Yan S, Xiang J, Ma X, Seshan VE, Hendrickson RC, ... もっと読む

1. 癌遺伝子活性化誘導早期老化癌遺伝子活性化誘導早期老化を調節するエンハンサー同定[出典]"Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence" Han R, Li L [..] Elkon R, Agami R. Genome Biol. ... もっと読む

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