[crisp_bio注] 2018-11-30更新; Wikipedia "Lulu and Nana"へのリンク追加; 2018-12-01更新
[概要]
[概要]
- 南方科技大学 (深圳)のJiankui He (賀建奎 副教授)は、HIV-1を発症しない"Berlin patient"の知見に基づいて１細胞期受精卵にHIV-1感染に関与するCCR5を標的とするCRISPR/Cas9遺伝子編集を加えた双生児(YouTubeではLuLu(露露)とNana(娜娜)と呼ばれている)が数週間前に誕生し、標的遺伝子以外のゲノムに異常はなく(オフターゲット編集はみられず）順調に成長していると、YouTubeで発表した (11月28日に第２回ヒトゲノム編集国際サミットで講演；以下の[出典の関連記事]の項にリンクあり)。
- 論文発表はなされていないが、MIT Technology Reviewの記事からリンクされている中国における治験登録Webサイトには、"Safety and validity evaluation of HIV immune gene CCR5 gene editing in human embryos"が登録されている (その後、登録が削除された (削除日不明))。
- 関連crisp_bio記事：
- 2018-12-04 CRISPR遺伝子改変ベビー中国で誕生か(4) 論点整理 - 関連記事を順次追加
- 2018-12-01 CRISPR遺伝子改変ベビー中国で誕生か(3) 生殖細胞系列ゲノム編集の臨床応用への道
- 2018-11-30 CRISPR遺伝子改変ベビー中国で誕生か(2)
[出典と関連記事]
- 賀建奎 第２回ヒトゲノム編集国際サミットで"露露と娜娜"講演・パネルディスカッション・質疑： Web cast日本時間2018-11-28 午後終了；Livestreamの再生はこちら(1時間18分過ぎから) ；講演のトランスクリプト掲載サイト；講演のスライド掲載サイト；
- 賀建奎のYouTube：About Lulu and Nana: Twin Girls Born Healthy After Gene Surgery As Single-Cell Embryos (4m43sec). The He Lab. YouTube 2018-11-25
- Wikipedia "Lulu and Nana" https://en.m.wikipedia.org/wiki/Lulu_and_Nana
- Science 2018-11-29 6:15 AM Organizers of gene-editing meeting blast Chinese study but call for ‘pathway’ to human trials. Normile D. "But it did not call for a global moratorium on similar studies..."
- A general statement at the conclusion of the Hong Kong summit: Statement by the Organizing Committee of the Second International Summit on Human Genome Editing 2018-11-29
- Science Translational Medicine 2018-11-28. (independent blog) After Such Knowledge - So now we know more about the CRISPR human baby story. And it’s even worse than it looked. Lowe D.
- Science. 2018-11-28. "‘I feel an obligation to be balanced.’ Noted biologist comes to defense of gene editing babies" - George Church takes a more nuanced view than many scientists on the recently revealed gene editing of human babies. Cohen J.
- Nature. 2018-11-28/2018-11-30改訂 "CRISPR-baby scientist fails to satisfy critics" Cyranoski D.
- Nature. 2018-11-27. How the genome-edited babies revelation will affect research. Cyranoski D.
- WIRED. 2018-11-27. Scientist Who Crispr’d Babies Bucked His Own Ethics Policy. Molteni M.
- The Conversation. 2018-11-27. The road to enhancement, via human gene editing, is paved with good intention. Evans J (Prof. Sociology, UCSD)
- The Guardian. 2018-11-27. [中国の反応] China orders inquiry into 'world's first gene-edited babies. Kuo L.; Gene-edited babies: no one has the moral warrant to go it alone. Hasson K, Darnovsky M.
- 南方科技大学の"無関係"との声明 The University was deeply shocked by this event and has taken immediate action to reach Dr. Jiankui HE for clarification. SUSTech 2018-11-26：報道から知り、驚愕し、学外で行われたこの事案の詳細を明らかにすべくDr. Jiankui HE (2018年2月から2021年1月まで無給のサバティカル)に連絡をとろうとしている
- 深圳和美醫院の親企業からの"無関係"との声明 CLARIFICATION ANNOUNCEMENT REGARDING CERTAIN MEDIA REPORTS 2018-11-27.
- 第２回ヒトゲノム編集国際サミット組織委員会の声明 (開催地 Hong Kong) Statement from the Organizing Committee on Reported Human Embryo Genome Editing. 2018-11-26.
- MIT Technology Review. 2018-11-25. EXCLUSIVE: Chinese scientists are creating CRISPR babies. Regalado A.
- 澎湃 (THE PAPER). 2018-11-26. [中国での報道] 南方科大对基因编辑婴儿不知情：深表震惊，贺建奎已停薪留职. 来源：澎湃新闻.
- AP(The Associated Press) NEWS. 2018-11-26. AP Exclusive: First gene-edited babies claimed in China. Marchone M.
- Nature. 2018-11-26. NEWS Genome-edited baby claim provokes international outcry. (This story will be updated throughout the day) Cyranoski D.
- Science. 2018-11-26. CRISPR bombshell: Chinese researcher claims to have created gene-edited twins. Normile D.
- STAT. 2018-11-26 What we know — and what we don’t — about the claim of world’s first gene-edited babies. Cooney E.: "At least one scientist came to He’s defense....."
- STAT. 2018-11-26. As a genome editing summit opens in Hong Kong, questions abound over China, and why it quietly bowed out. Begley S.
- STAT. 2018-11-26. [米国ライス大学からの協力者への対応] Rice University opens investigation into researcher who worked on CRISPR’d baby project. Joseph A.
- Gaetan Burgioによる第２回ヒトゲノム編集国際サミット賀建奎講演のコメント付き引用 (クロマトグラフの解読**など)
- (**)
Gaetan Burgio@GaetanBurgio
@pknoepfler @EricTopol Wow insane! Looking at the chromatograms again, all the alleles are mosaic !!!! We can still… https://t.co/0aOCopXa7q
2018/11/29 03:17:06
The problem here is the WGS method used is insufficient to rule out large deletions/mosaicism and allele dropout .… https://t.co/Zv7jEwTE8I
2018/11/28 15:22:07
- 2018年8月に開催されたCSHL CRISPR meetingでポスター発表あり
Jason Sheltzer@JSheltzerHe Jiankui presented a poster at the CSHL CRISPR meeting in August this year reporting that he detected only a sing… https://t.co/j4k1toKCPs
2018/11/26 12:56:51
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