1.ゲノムワイドCRISPR-Cas9スクリーンとin vivoスクリーンにより、急性骨髄性白血病(AML)の新たな治療標的を同定"Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS" Yamauchi T, ~ Maeda T. Ca ... もっと読む

出典"Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation" Zhang H, ~ Lyden D. Nat Cell Biol. 2018 Mar;20(3):332-343. Published online 2018 Feb 19. [News & Views] "Size matters in nanos ... もっと読む

1.TβRIIIを低発現するT細胞白血病/リンパ腫を標的とする低分子TJ191"2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells" El-Gazzar A, ~  ... もっと読む

1.RNPs用にin vitro転写(IVT)から生成されるgRNAの5'末端に存在するトリホスフェイトが、自然免疫応答を介して細胞死を誘導する"CRISPR RNAs trigger innate immune responses in human cells" Kim S, ~ Kim JS. Genome Res. 2018 Feb 22.ゲノム編集対象のヒトを含む動植 ... もっと読む

ACS Chem Biol. 2018 Feb 16pp 283-284 "[Editorial Letter]Special Issue on the Chemical Biology of CRISPR" Alyson G. Weidmann  and Amit Choudharypp 290–295 "Spotlight: A Conversation with Laura Kiessling and Jennifer Doudna" Laura L. Kiessling and Jenni ... もっと読む