blogging about crisp bio-S&T, especially CRISPR.


[出典] "Mapping human microbiome drug metabolism by gut bacteria and their genes" Zimmermann M, Zimmermann-Kogadeeva M, Wegmann R, Goodman AL. Nature 2019-06-03.; [NEWS & VIEWS] Microbes make metabolic mischief by targeting drugs. Lewis K, Strandwitz P. N ... もっと読む

[出典] "Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease" Kim S, Kwon SH [..] Dawson TM, Ko HS. Neuron 2019-06-26.概要PD患者の脳には、黒質緻密部 (substantia nigra pars compacta)におけるドーパミン作 ... もっと読む

[出典] "A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass" Liu X, Wei L, Dong Q, Liu L, Zhang MQ, Xie Z, Wang X. Aging (Albany NY) 2019-06-20. 細胞老化は、細胞の自律的腫瘍抑制を担う一方で、炎症性サイトカイン ... もっと読む

[出典] "Generating viable mice with heritable embryonically lethal mutations using the CRISPR-Cas9 system in two-cell embryos" Wu Y, Zhang J [..] Chen B, Wang S. Nat Commun. 2019-06-28.背景遺伝子ノックアウトモデルマウスは、in vivoでの遺伝子機能を解析に必 ... もっと読む

[出典] "Catalytically Active Cas9 Mediates Transcriptional Interference to Facilitate Bacterial Virulence" Ratner HK [..] Charpentier E, Weiss DS. Mol Cell 2019-06-27.背景CRISPR-Cas9を含むタイプII CRISPR-Casは病原菌と共生菌に高頻度に内在し、バクテリアの獲 ... もっと読む