blogging about crisp bio-S&T, especially CRISPR.


[出典] "Mitigating off-target effects in CRISPR/Cas9-mediated in vivo gene editing" Han HA, Pang JKS, Soh B. J Mol Med 2020-03-20.  A*STAR Institute of Molecular and Cell/シンガポール国立大学の研究チームが、in vitroおよび前臨床試験動物モデルにおけるCRIS ... もっと読む

[出典] "Bacterial alginate regulators and phage homologs repress CRISPR–Cas immunity" Borges AL [..] Bondy-Denomy. Nat Microbiol 2020-03-23. UCSFの研究グループは、CRISPR-Casがヌクレアーゼ活性を発揮する分子機構で ... もっと読む

[出典] "Engineering herbicide-resistant oilseed rape by CRISPR/ Cas9-mediated cytosine base-editing" Wu J [..] Zhang H, Wang Y. Plant Biotechnol J 2020-02-24. アブラナ (Brassica napus)の生産性の敵は雑草であり、除草剤に耐性を付与することが、効果的である。 ... もっと読む

[出典] OPINION ARTICLE "Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China [version 2; peer review: 2 approved]" Kruse RL (JHU). F1000Research.  First published: 31 Jan 2020, 9:72; Latest published ... もっと読む

[出典] "Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion" Xia S, Liu M, Wang C, Xu W [..] Sun F, Shi Z, Zhu Y, ... もっと読む