[出典] "Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells" Wang Y, Wu J, Chen H, Yang Y, Xiao C, Yi X [..] Ge J, Zhou W, Chu X, Chen C, Zhou X, Wang L, Guan K, Qu L. Sci Adv 2021-01-27. https://doi.org ...
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2021年01月
Cas12aのトランス切断活性と2D薄膜をベースとする電気化学発光バイオセンサによるSiglec-5の超高感度検出
[出典] "Exploring the Trans-Cleavage Activity of CRISPR-Cas12a for the Development of a Mxene Based Electrochemiluminescence Biosensor for the Detection of Siglec-5" Zhang K [..] Pan J. Biosens Bioelectron. 2021-01-26. https://doi.org/10.1016/j.bios.2021. ...
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ゲノムワイドCRISPRiスクリーンにより免疫チェックポイント受容体Siglec-7に特異的に結合する糖鎖を同定
[出典] "Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7" Wisnovsky S [..] Bertozzi CR. PNAS. 2021-01-25. https://doi.org/10.1073/pnas.2015024118 癌細胞はその表面を糖鎖で覆い、その糖鎖が免疫を ...
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カルジオリピン合成を担うPTPMT1が、肝臓癌細胞の低酸素環境での生存に必須
[出典] "Genome-wide CRISPR-Cas9 knockout library screening identified PTPMT1 in cardiolipin synthesis is crucial to survival in hypoxia in liver cancer" Bao M H-R, Yang C, Tse A P-W, Wei L [..] Wong C-M, Wong C C-L. Cell Rep 2021-01-26. https://doi.org/10 ...
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GLI1転写因子の第1イントロンをCRISPR/Cas9で編集するとヒトES 細胞は発生不全に到る
2021-01-30 21:00 論文URL修正[出典] "Crispr editing of the gli1 first intron abrogates gli1 expression and differentially alters lineage commitment" Galat Y [..] Galat V, Iannaccone PM. Stem Cells 2021-01-26. https://stemcellsjournals.onlinelibrary.wiley.c ...
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