ScCas9++: Streptococcus canis 由来Cas9の高効率・高精度版変異体[出典] "The ScCas9++ variant expands the CRISPR toolbox for genome editing in plants" Liu T [..] Liu Y-G, Zhu Q. J Integr Plant Biol. 2021-08-19. https://doi.org/10.1111/jipb.13164 State Key L …
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2021年08月
CRISPR/Cas12aとprimer exchange reaction (PER)のカップリングにより病原菌の超高感度検出を実現
Primer Exchange Reaction (PER) https://wyss.harvard.edu/media-post/primer-exchange-reactions/[出典] "Ultrasensitive detection of pathogenic bacteria by CRISPR/Cas12a coupling with a primer exchange reaction" Bu S [..] Liu W, Wan J. Sens Actuators B Chem. …
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蒸気・ナノバブル・光ポレーションを利用したCas9 RNPトランスフェクションを介して生体外の細胞工学を実現
蒸気・ナノバブル・光ポレーション: Vapor Nanobubble (VNB) Photoporation[出典] "Cas9 RNP Transfection by Vapor Nanobubble Photoporation for Ex Vivo Cell Engineering" Raes L [..] Braeckmans K. Mol Ther - Nucleic Acids. 2021-08-13 (Journal Pre-proof). https:/ …
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常染色体顕性視神経萎縮症 (DOA)患者由来のiPSCのCRISPR/Cas9遺伝子修復を介した正常化
DOA: dominant optic atrophy[出典] "CRISPR/Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in Dominant Optic Atrophy patient-derived iPSCs" Sladen PE [..] Yu-Wai-Man P, Cheetham ME. Mol Ther - Nucleic Acids. 2021-08-19 (Journa …
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CRISPR/Cas9によるイヌアデノウイルス2型のin vitro遺伝子機能改変
[出典] "In vitro functional genetic modification of canine adenovirus type 2 genome by CRISPR/Cas9" Sajib AM [..] Smith BF. Lab Invest 2021-08-20. https://doi.org/10.1038/s41374-021-00654-x Auburn Universityの研究グループからの論文．遺伝子組み換え腫瘍溶 …
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