多重度が極めて高い ultra-deep sequencing にて検証 [出典] "Ultra-deep sequencing reveals no evidence of oncogenic mutations or enrichment by ex vivo CRISPR/Cas9 genome editing in human hematopoietic stem and progenitor cells" Cromer MK, Basan VV [..] Port …
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2021年11月
腫瘍オルガノイド疾患モデルにより，肝転移性大腸癌の治療標的としてAURKAが浮かび上がってきた
[出典] "Disease modeling on tumor organoids implicates AURKA as a therapeutic target in liver metastatic colorectal cancer" Boos SL [..] Jung P. Cell Mol Gastroenterol Hepatol. 2021-10-23. https://doi.org/10.1016/j.jcmgh.2021.10.008; Graphical abstract ht …
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好熱性糸状菌Humicola insolensのCRISPR/Cas9ゲノム編集を初めて実現
[出典] "CRISPR/Cas9-mediated genome editing directed by a 5S rRNA–tRNA(Gly) hybrid promoter in the thermophilic filamentous fungus Humicola insolens " Fan C, Zhang W [..] Huang H, Xu X. Biotechnol Biofuels. 2021-10-23. https://doi.org/10.1186/s13068-021 …
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内在性サブタイプI-F CRISPR-CasシステムとMMEJを介して，Zymomonas mobilisの迅速ゲノム編集を実現
出典] "Endogenous CRISPR-assisted microhomology-mediated end joining enables rapid genome editing in Zymomonas mobilis " Sui X [..] He M, Peng N. Biotechnol Biofuels. 2021-10-24. https://doi.org/10.1186/s13068-021-02056-z 華中農業大学，Biomass Energy Te …
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