[注] PDX (Patient-derived xenografts)[出典] "WT1 and DNMT3A Play an Essential Function and Represent Therapeutic Vulnerabilities in Certain AML Samples, As Shown By CRISPR/Cas9 Mediated Knockout in PDX Models In Vivo" Ghalandary M [..] Jeremias I. Blood ( …
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2021年12月
新型コロナウイルスVOC変異株の免疫逃避能を迅速評価可能とするCoVariant-SCAN
[注] VOC (Variant of Concern, 懸念される変異株)出典] "Rapid test to assess the escape of SARS-CoV-2 variants of concern" Heggestad JT [..] Chilkoti A. Sci Adv. 2021-12-03. https://doi.org/10.1126/sciadv.abl7682 Duke UniversityとDuke University Medical …
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CRISPRaを介して腸細胞のApoAIとPON1を転写活性化すると,内皮細胞の炎症が緩和される
[注] ApoAI (アポリポタンパク質AI); PON1 (パラオキソナーゼ1)[出典] "CRISPR/dCas9 Transcriptional Activation of Endogenous Apolipoprotein AI and Paraoxonase 1 in Enterocytes Alleviates Endothelial Cell Dysfunction" Toma L [..] Stance CS. Biomolecules. 2021- …
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牛や羊に感染するカプリポックスウイルス (CaPV)の超高感度・ポイントオブケア検出を実現
[出典] "Ultra-sensitive and point-of-care detection of Capripoxvirus (CaPV) based on loop-mediated amplification (LAMP) and trans-cleavage activity of CRISPR/Cpf1" Chen X, Naie F [..] Li Y, Hugo D, Hou C. Analytica Chimica Acta 2021-11-25. https://doi.org …
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CRISPRiを介して多発性骨髄腫 (MM)の長鎖ノンコーディングRNA (lncRNA)依存性を同定
[出典] "Identifying Long Noncoding RNA Dependencies Using CRISPR Interference (CRISPRi)-Based Platform in Multiple Myeloma" Morelli E [..] Munshi NC. Blood. Blood (2021) 138 (Supplement 1): 894.https://doi.org/10.1182/blood-2021-151705 Dana-Farber Cancer …
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