[出典] "Two differentially stable rDNA loci coexist on the same chromosome and form a single nucleolus" Lazar-Stefanita L, Lou J, Haas MAB, Zhang W, Boeke JD. Proc Natl Acad Sci U S A. 2023-02-23. https://doi.org/10.1073/pnas.2219126120 [著者所属] NYU Lan …
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2023年03月
超高輝度なルシフェラーゼを深層学習を利用してデノボで設計
[出典] "De novo design of luciferases using deep learning" Yeh AH, Norn C [..] Baker D. Nature 2023-02-22. https://doi.org/10.1038/s41586-023-05696-3 [著者所属] U Washington, US Santa Cruz, UCLA, Xi'an Jiaotong U;News Release "Artificial intelligence con …
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CRISPR-Tagシステムを利用してB型肝炎ウイルス共有結合型環状DNAの動態を生細胞内で観察
[注] B型肝炎ウイルス(HBV);共有結合型環状DNA(cccDNA)[出典] "Illuminating the Live-Cell Dynamics of Hepatitis B Virus Covalently Closed Circular DNA Using the CRISPR-Tag System" Ding J [..] Yuan Z. mBio. 2023-02-22. https://doi.org/10.1128/mbio.03550-2 …
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癌免疫療法への耐性を、TBK1を標的とすることで克服する
[出典] "Targeting TBK1 to overcome resistance to cancer immunotherapy" Sun Y [..] Manguso RT, Jenkins RW. Nature. 2023-01-12. https://doi.org/10.1038/s41586-023-05704-6 [著者所属] Massachusetts General Hospital, Massachusetts General Hospital Cancer Cente …
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Cas9 RNPを介した二重遺伝子ターゲティングによるヒラタケのゲノム編集
[出典] "Double-gene targeting with pre-assembled Cas9 ribonucleoprotein for safe genome editing in the edible mushroom Pleurotus ostreatus " Boontawon T [..] Honda Y. FEMS Micobiol Lett 2023-02-22. https://doi.org/10.1093/femsle/fnad015 [著者所属] 京大、 …
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