[出典] "Excess of Guide RNA Reduces Knockin Efficiency And Drastically Increases On-Target Large Deletions" Chenouard V [..] Anegon I. iScience 2023-03-09 (Accepted). https://doi.org/10.1016/j.isci.2023.106399 [著者所属] Nantes U, genOway  https://www.ge …

[出典] "Precise homology-directed installation of large genomic edits in human cells with cleaving and nicking high-specificity Cas9 variants" Wang Q [..] Gonçalves MAFV. Nucleic Acids Res. 2023-03-17. https://doi.org/10.1093/nar/gkad165 [著者所属] Leide …

[注] 胃がん (Gastric Cancer: GC)；患者由来オルガノイド (patient-derived organoids: PDOs)；KDM1A (ヒストンリジンデメチラーゼ-1A)[出典] "CRISPR/Cas9 Screen in Gastric Cancer Patient-Derived Organoids Reveals KDM1A-NDRG1 Axis as a Targetable Vulnerability" M …