[出典] "Gene regulation analysis of patient-derived iPSCs and its CRISPR-corrected control provides a new tool for studying perturbations of ELMOD3 c.512A>G mutation during the development of inherited hearing loss" Liu X [..] Ling J, Feng Y. PLoS One 202 …
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2023年09月
CRISPRiによるTFのノックダウンに応答するゲノム全体のプロモーター活性を測定する超並列法, PPTP-seq
[注] TF (転写因子); TFのノックダウン (TFKD) [出典] "Genome-wide promoter responses to CRISPR perturbations of regulators reveal regulatory networks in Escherichia coli " HanY, Li W, Filko A, Li J, Zhang F. Nat Commun. 2023-19-16. https://doi.org/10.1038 …
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CRISPR-Cas12aをベースとするDNAレポーターを細胞膜に固定することで、迅速かつ高感度な癌細胞同定を実現
[出典] "FINDER: A Fluidically Confined CRISPR-Based DNA Reporter on Living Cell Membranes for Rapid and Sensitive Cancer Cell Identification" Yin Y [..] Zhang XB. Angew Chem Int Ed Engl. 2023-09-14. https://doi.org/10.1002/anie.202309837 [著者所属] Hunan …
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MSモデルの生体内ゲノムワイドCRISPRスクリーンを介して、T細胞のCNSヘの浸潤を制御する一連の必須遺伝子を同定
[注] MS (multiple sclerosis/多発性硬化症); CNS (central nervous system/中枢神経系)[出典] 論文 "A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model" Kendirli A, de la Rosa C, Lä …
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創造的思考のテストにおいて、AIは"平均的"人間に優るが、"最高な"人間には及ばない
[出典] "Best humans still outperform artificial intelligence in a creative divergent thinking task" Koivisto M, Grassini S. Sci Rep. 2023-09-14. https://doi.org/10.1038/s41598-023-40858-3 [著者所属] U Turku, U Bergen, U Stavanger. 創造性は従来、人間だけ …
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