[注] MGEs (mobile genetic elements/可動遺伝因子)[出典] REVIEW "New faces of prokaryotic mobile genetic elements: guide RNAs link transposition with host defense mechanism" Koonin EV, Krupovic M. Curr Opin Syst Biol. 2023-8-29. http://dx.doi.org/10.1016/j. …
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2023年09月
Cas9を介したノックインの精度と効率を、DNA修復タンパク質の組み合わせを融合することで改善
[出典] "Enhancing Precision and Efficiency of Cas9-Mediated Knockin Through Combinatorial Fusions of DNA Repair Proteins" Richardson RR [..] Poulopoulos A. CRSIRP J. 2023-09-15. https://doi.org/10.1089/crispr.2023.0036 [著者所属] U Maryland School of Medi …
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ガンビエハマダラカを対象とするCRISPR-Cas遺伝子ドライブの効率に遺伝的多様性と染色体逆位が及ぼす影響
[出典] "Measuring the Impact of Genetic Heterogeneity and Chromosomal Inversions on the Efficacy of CRISPR-Cas9 Gene Drives in Different Strains of Anopheles gambiae " Pescod P [..] Nolan T. CRISPR J. 2023-09-13. https://doi.org/10.1089/crispr.2023.0029 …
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キメラ抗原受容体 (CAR) をMTOR遺伝子座にターゲンティグすることで、CAR-T細胞療法を強化
[出典] "MTOR as a selectable genomic harbor for CRISPR-engineered CAR-T cell therapy" Levesque S [..] Doyon Y. bioRxiv 2023-09-06 (preprint). https://doi.org/10.1101/2023.09.14.557485 [著者所属] U Laval, U Laval Cancer Research Centre, Trev and Joyce Deel …
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[20230923更新] CD3δ型重症複合免疫不全症モデルにおいて、ABEによるT細胞生成回復を実証
2023-09-22 Signal transduction and targeted therapy 誌のハイライト記事の書誌情報と挿入図を以下に引用:"Base editing: a novel cure for severe combined immunodeficiency" Ha TC, Morgan M, Schambach A. Sig Transduct Target Ther. 2023-09-18. https://doi.org/1 …
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