[出典] “Novel structure of the anti-CRISPR protein AcrIE3 and its implication on the CRISPR-Cas inhibition” Kim DY, Jan JH, Lee SY, HA HJ, Park HH. Biochem Biophys Res Commun. 2024-05-23. https://doi.org/10.1016/j.bbrc.2024.150164 [所属] Chung-Ang U (Se …
続きを読む
2024年05月
[レビュー] 癌に見られる代謝の変化と次世代CAR-T細胞療法への示唆
[出典] REVIEW “Altered cancer metabolism and implications for next-generation CAR T-cell therapies” Ramapriyan R, Vykunta VS, Vandecandelaere G, Richardson LGK, Sun J, Curry WT, Choi BD. Pharmacol Ther. 2024-05-17. https://doi.org/10.1016/j.pharmthera.2 …
続きを読む
CRISPRiスクリーンにより, マクロファージの分化と炎症シグナル伝達を制御する多機能遺伝子座としてlncRNA, LOUP, を同定
[出典] “CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation and inflammatory signaling” Halasz H, Malekos E, Covarrubias S [..] Carpenter S. Proc Natl And Sci U S A. 2024-05-28. https://doi.or …
続きを読む
相同組換えのためのDNAドナーテンプレートからの漏出発現を排除するrAAVキャプシド変異体を開発
[出典] “rAAV capsid mutants eliminate leaky expression from DNA donor template for homologous recombination” Ling C, Yu C, Wang C et al. Nucleic Acids Res 2024-05-23. https://doi.org/10.1093/nar/gkae401;挿入図はグラフィカルアブストラクトから引用 CRISP …
続きを読む
造血幹細胞・前駆細胞 (HSPC)のプライム編集 (PE)の効率を, ヌクレオチド代謝の調節を介して大幅に改善
[注] HSPC (hematopoietic stem and progenitor cell) [出典] “Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism” Levesque S[..] Bauer DE. Nat Biotechnol. 2024-05-28. https://doi.org/10.1038/s41587-024-02 …
続きを読む