- 嚢胞性線維症の原因変異CFTR R553Xの修正 [出典] "Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells" Kulhankova K, Cheng AX, Traore S [..] Guay D. Nucleic ...
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2024年09月
Chem-CRISPR/dCas9<FCPF>: 化学的誘導エピゲノム編集法
[出典] "Chem-CRISPR/dCas9FCPF: a platform for chemically induced epigenome editing” Altinbay M, Wang J, Chen J, Schäfer D [..] Cheng X. Nucleic Acids Res. 2024-09-24. https://doi.org/10.1093/nar/gkae798 [所属] Goethe U Frankfurt am Main, Frankfurt Cance ...
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Cas9ニッカーゼを介したCAG/CTGリピートの収縮は転写に依存し複製には依存しない
[出典] "Cas9 Nickase-mediated contractions of CAG/CTG repeats are transcription-dependent and replication-independent" Larin M [..] Dion V. NAR Mol Med 2024-09-23. https://doi.org/10.1093/narmme/ugae013 [所属] UK Dementia Research Institute at Cardiff U, ...
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細胞内のdNTPレベルを上げるとプライム編集 (PE) 効率が向上する
[出典] "Increasing intracellular dNTP levels improves prime editing efficiency" Liu P, Ponnienselvan K [..] Wolfe SA. Nat Biotechnol. 2024-09-25. https://doi.org/10.1038/s41587-024-02405-x [所属] U Massachusetts Chan Medical School. 初代細胞では、細胞内 ...
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CRISPR-Cas9療法の臨床研究に向けて, 哺乳類にわたる超保存エレメントを標的とするガイドRNAを同定・利用
[出典] "Identification of a Guide RNA Targeting an Ultraconserved Element for Evaluation of Cas9 Genome Editors Across Mammalian Species" Gowen B [..] Wei SC. CRISPR J. 2024-09-23. https://doi.org/10.1089/crispr.2024.0053 [所属] Spotlight Therapeutics, In ...
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