[出典] "Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements" Chardon FM, McDiarmid TA [..] Ahituv N, Shendure J. Nat Commun. 2024-09-18. https://doi.org/10.1038/s41467-024-52490-4 [所属] UW Seattle, Seattle Hub for Syntheti …
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2024年09月
DNA生産とゲノム編集のためのレトロンの実験的センサス
[出典] "An experimental census of retrons for DNA production and genome editing" Khan A [..] Shipman SL. Nat Biotechnol. 2024-09-17. https://doi.org/10.1038/s41587-024-02384-z [所属] Gladstone Institute of Data Science and Biotechnology, Graduate Program …
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[解説] 真核生物由来のCRISPR-Cas様RNAガイドDNA切断酵素”Fanzor"とは
[出典] Preview "Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s?" Omura SN (大村紗登士), Nureki O (濡木 理). Cell. 2024-09-19. https://doi.org/10.1016/j.cell.2024.08.022 CRISPR-Cas9によるヒトゲノム編集のパイオニ …
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エピゲノム編集を介して父親由来Ube3aのサイレンシングを解除することで, アンジェルマン症候群モデルマウスの症状を緩和
[出典] "Epigenetic editing alleviates Angelman syndrome phenotype in mice by unsilencing paternal Ube3a” Liu Ya, Lou S, Liu Yu [..] Huang X, Xiong Z, Yang H, Zhou C. Cell Discovery. 2024-09-17. https://doi.org/10.1038/s41421-024-00727-3 [所属] Shanghai T …
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椎間板における炎症性受容体の治療的CRISPRエピゲノム編集
[出典] "Therapeutic CRISPR Epigenome Editing of Inflammatory Receptors in the Intervertebral Disc" Stover JD, Trone MAR [..] Bowels RD. Mol Ther. 2024-09-17. https://doi.org/10.1016/j.ymthe.2024.09.022 [所属] U Utah 腰痛(low back pain: LBP)は世界的な身 …
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