[出典] UA 20190382752A1 Method for Re-Expression of Different Hypermethylated Genes Involved in Fibrosis, Like Hypermethylated RASAL1 and Use Thereof in Treatment of Fibrosis As Well As Kit of Parts for Re-Expression of Hypermethylated Genes Including RASAL1 in a Subject
  • 公開日:  2019-12-10
  • 発明者: Zeisberg E, Xingbo X.
  • 権利者: Georg-August-Universität Göttingen, Universitätsmedizin
  • CRISPRa: dCas9, dHFCas9またはCpf1に、TET3触媒ドメイン (TET3CD)またはTET1触媒ドメイン (TET1CD)を融合
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  • "High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis" Xu X [..] Zeisberg EM,  Zeisberg M. Nat Commun. 2018 Aug 29.