[出典] "CRISPR-associated tranposase systems and methods of use thereof" US20200190487 A1.
- 公開日 2020-06-18; 発明者 Zhang F, Strecker J, Ladha A; 権利者 Broad Inst, MIT
- 関連crisp_bio記事: 2019-06-06 Cas12kとトランスポザーゼの協働により、Cas9と異なりDSBを介さずに、ドナーDNAの効率的挿入を実現; "RNA-guided DNA insertion with CRISPR-associated transposases" Strecker J [..] Zhang F. Science 2019-06-06.
Science論文はE. coliでの実証であったが、特許文書では、動植物細胞とヒト細胞も適用対象にあげられている: "In some embodiments, the cell is a prokaryotic cell. In some embodiments, the cell is a eukaryotic cell. In some embodiments, the cell is a mammalian cell, a cell of a non-human primate, or a human cell. In some embodiments, the cell is a plant cell. In another aspect, the present disclosure provides an organism or a population thereof comprising the cell herein"
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