[リンクのみ] Engineered CRISPR/Cas9 enzymes improve discrimination by slowing DNA cleavage to allow release of off-target DNA. Liu MS [..] Johnson KA, Taylor DW. Nat Commun 2020-07-17
[K. A. JohnsonとD. W. Taylorらの先行研究紹介記事]
[参考論文]
[K. A. JohnsonとD. W. Taylorらの先行研究紹介記事]
[参考論文]
- [EDITORIAL] Understanding off-target effects through hybridization kinetics and thermodynamics. Nazipova NN, Shabalina SA. Cell Biol Toxicol 2019-12-10.
- Enhancing gene editing specificity by attenuating DNA cleavage kinetics. Miller JC [..] Rebar EJ. Nat Biotechnol 2019-07-29; 2019-07-30 ZFNのオンターゲット編集活性を損なわずオフターゲット編集活性を検出限界未満まで抑制する変異導入
- Hybridization Kinetics Explains CRISPR-Cas Off-Targeting Rules. Klein M, Eslami-Mossallam B, Arroyo DG, Depken M. Cell Rep. 2018-02-06.
- [PERSPECTIVE] Lessons from Enzyme Kinetics Reveal Specificity Principles for RNA-Guided Nucleases in RNA Interference and CRISPR-Based Genome Editing. Bisaria N, Jarmoskaite I, Herschlag D. Cell System 2017-01-25.
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