[出典] REVIEW "Harnessing CRISPR-Cas system diversity for gene editing technologies" McKay A, Burgio G. J Bio Res. 2021-03-26. https://doi.org/10.7555/JBR.35.20200184

構成
  • はじめに
  • CRISPR-Cas干渉と細胞内在修復機構 (NHEJ; HDRとMMEJ)
  • CRISPR-Casシステムの多様性と進化
  • クラス2エフェクター達 (Cas9, Cas12, Cas12i/f, Cas12k-tnsB-tnsC-tniQ complex, Cas12g, and Cas13)- 遺伝子編集ツールのベースとなるモノマー・エンドヌクレアーゼ
  • おわりに (参考文献 103編)
図表一覧
  • Fig. 1 Steps in CRISPR-Cas mediated acquired immunity. 
  • Fig. 2 Overview of the main double-stranded break repair mechanisms (NHEJ; HDRとMMEJ).
  • Fig. 3 Outline of the current parsimonious classification schemes for CRISPR-Cas systems.
  • Fig. 4 Overview of the computational pipeline used to uncover CRISPR associated proteins.
  • Fig. 5 Gene editing strategies developed using standalone type I systems.
  • Fig. 6 Activities of Class 2 CRISPR-Cas effectors utilized in gene editing systems. 
  • Table 1 Properties of most commonly used Cas9 orthologs in gene editing (Sp-, Fn-, Sa-, Nm-, St1-,  St3-, Cj-).