Proceedings: AACR (米国癌学会) Annual Meeting 2017; April 1-5, 2017; Washington, DC

http://cancerres.aacrjournals.org/content/77/13_Supplement

 

Experimental and Molecular Therapeutics

  • LB-116: Functional genomics screening using LentiArray™ CRISPR libraries and CellSensor™ assays
  • LB-118: Characterization of lineage vs. context-dependent essential genes in multiple myeloma using CRISPR-Cas9 genome editing
  • LB-282: Two different strategies of delivery CRISPR/Cas9 system to gene edit rs4644 SNP in LGALS3 gene
  • 4123: CRISPR-Cas9 and siRNA screening in primary human immune cells
  • 5090: Efficient KO of PD1 into primary T cells using a new non-integrative lentiviral particle expressing CRISPR/Cas9 system
  • 5094: Precision therapeutic targeting of oncogenic FGFR3 fusions using CRISPR-Cas9 genome-editing in urothelial cancer
  • 5096: Targeted ablation of essential oncogenes in rhabdomyosarcoma with CRISPR/Cas9 gene therapy

Immunology


Cancer Chemistry


Molecular and Cellular Biology, Genetics

  •  417: Defining molecular mechanisms of resistance to glioblastoma immunity using a novel CRISPR/Cas9 in vivo loss-of-function screening platform
  • 1444: Validation of prostate cancer risk variants by CRISPR/Cas9 mediated genome editing at the MSMB locus
  • 1512: Functional characterization of novel transcription-regulating cancer drug targets, CDK8 and CDK19, using CRISPR/Cas9 knockout and a highly selective CDK8/19 kinase inhibitor
  • 2431: Single cell gene expression profiling in breast cancer cells with the Her2/neu gene knockout by CRISPR-Cas9
  • 3039: Combinatorial CRISPR-Cas9 gene knockout to enable genetic interaction mapping in human cells
  • 3464: CRISPR-mediated inactivation of ATRX and DAXX in pancreatic neuroendocrine tumor cell lines
  • 4988: Genome-wide CRISPR screen and metabolite profiling reveal a new mechanism of methotrexate sensitivity
  • 5380: Inactivation of endogenous genes in cancer cells using targeted promoter DNA methylation via CRISPR-DNMT3a fusion protein

Tumor Biology

  • 2810: Using CRISPR/Cas9 to generate primary soft tissue sarcoma in genetically engineered and wild-type mice
  • 4844: CRISPR-generated BAP1 knockdown in uveal melanoma cell lines affects organotropism