# 1
CRISP_SCIENCE@ScienceCrispCas13a: Molecular Architecture for RNA-Guided RNA Cleavage
2017/07/31 06:30:27
cryoEM/SAD LbuCas13a-crRNA;+target RNA #CRISPR
Cell 0727 https://t.co/SXia91KoN7
# 2
CRISP_SCIENCE@ScienceCrisp5V8K: HbRC structure; 2017/07/31 AUTH -- 編集処理済、登録者の確認・同意待ちStructure of a symmetric photosynthetic reaction center– photosystem
2017/07/28 19:53:44
P-5V8K Science 0727 https://t.co/k1ogh4bX7b
..ancestral reaction center
# 3
CRISP_SCIENCE@ScienceCrisp5VRE:crystal structure of a lysosomal potassium-selective channel TMEM175 homolog from Chamaesiphon Minutus (3.299 Å)The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture
2017/07/27 07:48:09
Nature 0719 https://t.co/vC5vj3UPA1
P-5VRE (3.299 )
# 4
# CRISP_SCIENCE@ScienceCrispOpen and closed structures reveal allostery and pliability in the HIV-1 envelope spike
2017/07/25 06:58:43
Nature 0712-20 https://t.co/vaTIGsLppG
# 5
CRISP_SCIENCE@ScienceCrisp5XMI: ATP-bound Vps4E233Q hexamer; 2017/07/31 AUTH -- 編集処理済、登録者の確認・同意待ち 2017/07/31Cryo-EM struct. of the ATP-bound Vps4^{E233Q} hexamer & its complex with Vta1 at near-atomic reso,
2017/07/24 06:58:18
Nat Commun 0717 https://t.co/Lj6wTKnnuR
5XMK: ATP-bound Vps4E233Q–Vta1 complex; 2017/07/31 AUTH -- 編集処理済、登録者の確認・同意待ち
EMD-6735 (without mask), EMD-6733 (with mask), EMD-6736 (without mask) and EMD-6734 (with mask) 20170731 未公開
# 6
CRISP_SCIENCE@ScienceCrisp5VI8: Structure of a mycobacterium smegmatis transcription initiation complex with an upstream-fork promoter fragment (2.76 Å)Structural insights into the mycobacteria transcription initiation complex... X-ray
2017/07/24 06:51:50
P-5VI8 (2.76 ) Nat Commun 0713 https://t.co/oc1WzVDYmt
# 7
CRISP_SCIENCE@ScienceCrisp5VYC: Crystal structure of the human 40S ribosomal subunit in complex with DENR-MCT-1 (6 Å)Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1
2017/07/24 05:50:11
Cell Rep 0718 https://t.co/Wjys7NVXn8 P-5VYC (6.0 )
# 8
CRISP_SCIENCE@ScienceCrisp5OA9: Human translation re-initiation complex containing eIF2D (1.8 Å)Structural and Functional Insights into Human Re-initiation Complexes
2017/07/24 05:49:50
Mol Cell 0718 https://t.co/3ldngQFUal
5OA3: eIF2D complex; 20170731 REPL -- 登録者より新しい座標を受理、再処理が必要
EMD-3770: 20170731 未公開
# 9
CRISP_SCIENCE@ScienceCrisp5W81: Phosphorylated, ATP-bound structure of zebrafish cystic fibrosis transmembrane conductance regulator (CFTR)Conformational Changes of zebrafish CFTR upon Phosphorylation and ATP Binding
2017/07/23 20:15:05
Cell 0720 https://t.co/iRw6LRV8Pn
P-5… https://t.co/yAnG8jZXtM
EMD-8782 (3.37 Å)
#10
CRISP_SCIENCE@ScienceCrispEMD-6770 20170731 未公開Cryo-EM Structure of the Nav1.4-β1 Complex from Electric Eel
2017/07/23 20:14:09
Cell 0720 https://t.co/xfAHWdPxlF
P-5XSY E-6770
5XSY: EeNav1.4-β1 complex; 20170731 REPL -- 登録者より新しい座標を受理、再処理が必要
#11
CRISP_SCIENCE@ScienceCrisp#12#PDIS
2017/07/23 06:34:28
Probing Hydrophobic Binding Pocket of GPR34 by Docking-Aided Structure–Activity Analy.
J Med Chem 0723 https://t.co/pWMHZDNoQk
LysoPS
CRISP_SCIENCE@ScienceCrisp5VVJ: half-site-bound; 20170731 HPUB -- 編集処理完了、論文の公開まで公開待ちStructures of the #CRISPR genome integration complex
2017/07/21 13:01:10
Science 0720 https://t.co/Vk4iDypTYa
.. molecular mechanism of… https://t.co/sQmCHmgAky
5VVK; pseudo-full-site-bound; 20170731 HPUB -- 編集処理完了、論文の公開まで公開待ち
5VVL:pseudo-full-site-bound with Ni2+; 20170731 HPUB -- 編集処理完了、論文の公開まで公開待ち
EMD-8827 20170731 未公開
5WFE: 20170731 REPL -- 登録者より新しい座標を受理、再処理が必要
#13
CRISP_SCIENCE@ScienceCrisp"spectroscopic (namely, fluorescence, NMR, and CD) and biochemical (proteolysis degradation) ; protein ligation assay (PLA); NUPR1 knock-out cells by CRISPR/Cas9n"Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B
2017/07/20 06:48:35
PNAS 0718 https://t.co/TwWv2xh4h4
#14
CRISP_SCIENCE@ScienceCrisp#15[REVIEW]Revisiting the structure of haemoglobin and myoglobin with cryo-EM
2017/07/18 10:13:28
J Mol Biol 0708 https://t.co/4o5DpjDJ5x
several mega-Da ~ 64kDa
CRISP_SCIENCE@ScienceCrisp5TUD: Structural Insights into the Extracellular Recognition of the Human Serotonin 2B Receptor by an Antibody (3 Å)...the extracellular recognition of the human serotonin 2B receptor by an antibody
2017/07/18 08:38:11
PNAS 0717 https://t.co/tv4B94f1u4
femtosecond XFEL
#16
CRISP_SCIENCE@ScienceCrisp"Countermeasures Against Chemical Threats (CounterACT) project... how to combat toxic nerve agents such as sarin and VX"Space station project seeks to crystalize the means to counteract nerve poisons
2017/07/18 07:13:14
NIH News Releases 0717 https://t.co/elGVADjHEc
AChE enzyme
#17
CRISP_SCIENCE@ScienceCrisp"15,000 de novo designed miniproteins.....2500 stable designed proteins in four basic folds"Global analysis of protein folding using massively parallel design, synthesis, and testing
2017/07/15 08:06:54
Science0714 https://t.co/qxqxU08r9y
#18
CRISP_SCIENCE@ScienceCrispA nanosecond time-resolved XFEL analysis of structural changes associated with CO release from cytochrome c oxidase https://t.co/NdNNSiMRW0
2017/07/15 08:03:37
CRISP_SCIENCE@ScienceCrispEMD-8750 20170731 未公開Subunit conforma. variation within individual GroEL oligomers resolved by Cryo-EM
2017/07/15 07:51:10
PNAS 0714 https://t.co/st0hFYAqgc
.beyond ensemble average
5W0S: 20170731 AUTH -- 編集処理済、登録者の確認・同意待ち
#20
CRISP_SCIENCE@ScienceCrispEMD-8749: the complex of Streptococcus progenies Cas9 with sgRNA and AcrIIA4 (3.9Å)Disabling Cas9 by an anti-CRISPR DNA mimic
2017/07/13 06:26:32
Sci. Adv. 0712 https://t.co/PT3ygSlgb8
PDB ID 5VZL EMD-874 (HPUB) https://t.co/ZMw2oqpf7T
5VZL: cryo-EM structure of the Cas9-sgRNA-AcrIIA4 anti-CRISPR complex
#21
CRISP_SCIENCE@ScienceCrispStructure of Full-Length SMC and (mechanochemical) Rearrangements Required for Chromosome Organization
2017/07/11 07:50:30
Mol Cell 0706 https://t.co/9GqP74ss0q
#22
CRISP_SCIENCE@ScienceCrisp3WV6: Crystal Structure of a protease-resistant mutant form of human galectin-9 (1.95 Å)#PDIS Crystal Structure of a protease-resistant mutant form of human galectin-9
2017/07/11 07:48:02
Biochem Biophys Res Commun 0704… https://t.co/AeuJQLIf5s
#23
CRISP_SCIENCE@ScienceCrisp5UJ6: Crystal Structure of Bacteroides Uniformis beta-glucuronidase (1.9 Å)GUSome(β-Glucuronidases-ome) : total 3013/unique 279 in 6 structural catego.; 139 persons in HMP DB
2017/07/08 15:22:49
Structure 0705 https://t.co/v4lQGilhfe
#24
CRISP_SCIENCE@ScienceCrispCryo-eM structure of the protein-conducting ERAD channel Hrd1 with Hrd3
2017/07/08 14:42:16
Nature 0706 https://t.co/TuwbFmp7dn
aqueous channel & lateral gate
#25
CRISP_SCIENCE@ScienceCrisp#26FRel: Direct Imaging of Protein Stability and Folding Kinetics in Hydrogels
2017/07/07 16:10:04
ACS Appl Mater Interfaces 0705 https://t.co/kKLnV3dWOi
FRET
CRISP_SCIENCE@ScienceCrispStructural basis of N-acyltransferase reaction mechanism in Lnt(P. aeruginosa; E. coli)
2017/07/06 17:58:39
P-5N6H/L/M Nat Commun0704… https://t.co/wIi8X949rR
#27
CRISP_SCIENCE@ScienceCrispCrystal structures of agonist (AM11542/AM841)-bound human cannabinoid receptor CB1 (2.80/2.95 res.)
2017/07/06 13:39:28
Nature 0705 https://t.co/XqExtcOVqG
#28
CRISP_SCIENCE@ScienceCrispCryo-EM struct. of tau filaments from Alzheimer’s disease
2017/07/06 13:09:31
Nature 0705 https://t.co/h1nf6NlMql
Filament=2 profilaments=stack of C-shaped tau
CRISP_SCIENCE@ScienceCrispSBDD(構造に基づく薬剤設計)で新規結核菌薬開発:ポリケタイド合成酵素Pks13のチオエステラーゼ活性を標的としてSBDDしたリード化合物TAM16は第一選択薬イソニアジドと薬効同等・耐性発生率は〜100分の1
2017/07/04 14:56:44
Cell 0629 https://t.co/MrtMdypsxL
#30
CRISP_SCIENCE@ScienceCrisp#31ScipionCloud: .. cryo electron microscopy image processing on commercial and academic clouds..
2017/07/03 08:56:41
J Struct Biol 0625 https://t.co/kFDgtfmgiU
CRISP_SCIENCE@ScienceCrisp#32Cryo-EM: beyond the microscope
2017/07/03 07:53:33
Curr Opin Struct Biol 0621 https://t.co/rv7Tnok6kq
ヘテロな構造の画像処理、膜蛋白質の安定化、plunge-frozenサンプル調整等の技術
CRISP_SCIENCE@ScienceCrispCryo-EM struct. of Type I #CRISPR T. fuscathat Cascadea with: seed open (3.8 ) and full R-loop (3.3 )
2017/06/30 22:38:46
Cell 0629 https://t.co/XnlQLTV7GV
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