[出典] Review "Coding, or non-coding, that is the question" Poliseno L, Lanza M, Pandolfi PP. Cell Res 2024-07-25. https://doi.org/10.1038/s41422-024-00975-8 [所属] Oncogenomics Unit (ISPRO, Italy), Institute of Clinical Physiology, U Siena, U Turin, Renown Institute for Cancer (Nevada System of Higher Education) [兼任]；参考文献275件を含む21頁

Introduction

Bifunctional genomic loci express mRNAs and ncRNAs

　Fig. 1: Bifunctional genomic loci express mRNAs and ncRNAs
    [右図に引用].

Expression of an mRNA and a ncRNA depending on the exons spliced
    together

Expression of a sense mRNA and an antisense ncRNA

Expression of an mRNA from exons and of a ncRNA from introns of the same pre-mRNA

　Fig. 2: Bifunctional mRNAs exert coding functions and non-coding functions.

Bifunctional mRNAs exert non-coding functions as well

　The 5′UTR exerts non-coding functions

　The CDS exerts non-coding functions

　The 3′UTR exerts non-coding functions

　Table 1 List of mRNAs that exert ceRNA activity in human cancer due to their 3'UTR.

Bifunctional ncRNAs exert coding functions as well

　Fig. 3: Bifunctional ncRNAs exert non-coding functions and coding functions

　Translation of pri-miRNAs

　Translation of lincRNAs

　Table 2 List of lincRNAs and PGs that are translated into peptides/proteins with a role in human cancer.

　Translation of PGs

　Translation of circRNAs

　Table 3 List of circRNAs that are translated into peptides with a role in human cancer.

Concluding remarks

　Fig. 4: The complexity of expression and function of the coding and non-coding products derived from
    the same bifunctional gene. [左下図に引用]

　Fig. 5: Concordant or discordant impact of the coding and non-coding products derived from the same bifunctional gene in cancer. [右上図に引用]