[出典] Review "Gene drives: an alternative approach to malaria control?" Naidoo K, Oliver SV. Gene Ther. 2024-07-22. https://doi.org/10.1038/s41434-024-00468-8 [所属] Witwatersrand U, National Health Laboratory Service, National Institute for Communicable Diseases of the National Health Laboratory Service；参考文献 138件を含む13頁
南アフリカの研究チームによる、ベクター制御、特にマラリアに対する遺伝子ドライブの利用と進歩を対象とするレビュー：
[構成]
- Introduction
- Strategies to control mosquito populations
- Genetic control of mosquitoes using gene drives
- Suppression vs modification gene drives
- Inhibiting parasite development in mosquitoes
- Controlling gene drives
- Future perspectives for utilisation of gene drives
- Resistance to gene drives and methods of mitigation
- Summary
[図表一覧]
- Fig. 1: Timeline of key events in the development of gene drive systems in mosquitoes
- Fig. 2: Creating a CRISPR-based gene drive.
- Fig. 3: Comparison of Mendelian versus gene drive inheritance patterns.
- Fig. 4: Gene drive population suppression vs replacement strategies.
- Fig. 5: Stages of potential genetic intervention during the life cycle of the malaria parasite in the mosquito.
- Fig. 6: Population of Plasmodium parasites at each developmental stage.
- Table 1 Summary of recent gene drive suppression or replacement studies.
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