Genomic recordings to reconstruct cell history

Design components in genomic recording

Figure 1. Reconstructing cell signaling history with genomic recording circuits.

Programmable genome editors for recording (Cas9, Cas12a, BEs, PEs) 

Retrieving genomic recordings

Molecular sensors to convert cellular events into genomic recordings

Figure 2. Molecular sensors for cellular events with genome editing outputs.

DNA-based sensors of cell states and signaling

RNA-based sensors of cell states and signaling

Protein-based sensors of cell states and signaling

Figure 3. Protein design for novel sensor development.

Molecular circuits to convert sensor outputs into genomic recordings

Figure 4. Molecular circuits to enhance sensitivity and specificity of signal conversion.

Concluding remarks

Outstanding questions (5 items)