ノースカロリナ州立大学のRodolphe Barrangou教授らは今回、Current Opinion in Microbiology 誌刊行レビューにて、バクテリオファージを用いて、様々なCRISPRシステムを送達する最近の進歩について考察し、組換えファージが一般的に、微生物群集の機能と構成を合理的に設計するための、他に類を見ない効果的な手段となると結論づけている。
[構成]
- Introduction
- Phage-mediated CRISPR-Cas delivery modalities
- Diversity of Cas effectors
- Functionalizing Cas effectors
- Applications of phage-encoded CRISPR-Cas systems
- Enabling technologies for phage engineering
- Challenges and future perspectives
[図表リスト]
- Figure 1. Strategies for phage-mediated delivery of CRISPR-Cas systems. [左下図に引用]
- Figure 2. Two-step phage engineering strategy. [右上図に引用]
- Table 1. Select phages with engineering methods and outcomes.
- Table 2. Applications of engineered phages in diverse media.
[出典]
- Review "Phage-mediated delivery of CRISPR payloads" Beckley J, Barrangou R. Curr Opin Microbiol. 2026-01-16. https://doi.org/10.1016/j.mib.2025.102704 [所属] Department of Food, Bioprocessing and Nutrition Sciences/North Carolina State University
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