- 中国科学院微生物研究所/中国科学院大学のHua Xiang教授が責任著者となっているmLife 誌刊行レビュー
[構成]（参考文献141件を含む14頁）
INTRODUCTION
DIVERSITY OF DEFENSE SYSTEMS
Surface barriers
Nonspecific intracellular defense
Small-molecule arsenal
Host modi cation systems.
Argonaute systems.
Reverse transcriptase (RT)
Prophage‐induced chromosomal islands (PICIs)
Second‐messenger signaling systems
Toxin–antitoxin (TA) systems and Abi
Specific adaptive defense: CRISPR–Cas systems
Mechanism of CRISPR–Cas systems.
CreTA safeguard systems.
CRISPR–Cas ancestors.
Synergistic defense networks
EVOLUTIONARY ADAPTATION AND ARMS RACE DYNAMICS
Co-evolution of defense systems and anti-defense systems
HGT and population‐level immunity
RNA–protein co-evolution in defense systems
Prokaryotic origin of eukaryotic immune system
CONCLUDING REMARKS
[図表一覧]
- Figure 1. Diversity of prokaryotic defense mechanisms.
- Figure 2. Surface barriers preventing phage attachment and entry.
Figure 3. Key intracellular antiviral defense mechanisms in prokaryotes. - Figure 4. Evolutionary adaptation and arms race dynamics [右図に引用].
- Table 1. Structural and functional characteristics of novel prokaryotic defense systems.
[出典]
- Review "Prokaryotic defense systems: Diversity and evolutionary adaptation" Yang C, Gong L, Guo J, Xiang H. mLife. 2026-02-21. https://doi.org/10.1002/mlf2.70068 [所属] Institute of Microbiology CAS (中国), U CAS, Tianjin Institute of Industrial Biotechnology
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