[出典] "Precise large-fragment deletions in mammalian cells and mice generated by dCas9-controlled CRISPR/Cas3" Li J, Zhao D, Zhang T [..] Lai L, Sui T, Li Z. Sci Adv. 2024-03-15. https://doi.org/10.1126/sciadv.adk8052 [所属] Jilin U, Guangzhou Institutes ...
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カテゴリ: CRISPR
変形性関節症の多重炎症バイオマーカーのPOC定量化を, ガラス繊維によるサンプリングとCRISPR-Cas12aイムノセンシングで実現
[注] POC (Point-Of-Care)[出典] "CRISPR-Cas12a immunosensing on glass fiber for point-of-care quantification of multiple inflammation biomarkers in osteoarthritis" Zou S, Li J [..] Tian K, Liu G. Device 2024-03-12. https://www.cell.com/device/pdf/S2666-99 ...
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DNAセンシングのためのLNA修飾スプリットアクチベーターを介した自己触媒的CRISPR-Cas増幅効果
[出典] "An autocatalytic CRISPR-Cas amplification effect propelled by the LNA-modified split activators for DNA sensing" Sun K [..] Geng J. Nucleic Acids Res 2024-03-13. https://doi.org/10.1093/nar/gkae176 [所属] West China Hospital (Sichuan U), Tianfu Ji ...
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標的のDNAとRNAによるCRISPR-Cas12aヌクレアーゼ活性化の決定因子
[出典] "Determinants of CRISPR Cas12a nuclease activation by DNA and RNA targets" Nalefski EA [..] Madan D. Nuceic Acids Res. 2024-03-13. https://doi.org/10.1093/nar/gkae152 [所属] Global Health Labs, Inc CRISPPR-Cas12aは、標的の特定の二本鎖 (ds-) または ...
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分子糊 (molecular glue) によって制御されるコンパクトなタンパク質分解タグのファージ支援連続進化
[出典] "Continuous evolution of compact protein degradation tags regulated by selective molecular glues" Mercer JAM, DeCarlo SJ, Burman SSR [..] Choudhary A, Fischer ES, Liu DR. Science 2024-03-15. https://doi.org/10.1126/science.adk4422 [所属] Broad Inst ...
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