[出典] "Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo" Zhang H [..] Sontheimer EJ. bioRxiv 2023-03-20 [preprint]. https://doi.org/10.1101/2023.03.20.533459 [著者所属] U Massachusetts Chan Medical School, Broad Institute of Har ...
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カテゴリ: CRISPR
ヒト細胞を対象とするCRISPRスクリーンにより、トキソプラズマの適応度関連遺伝子を同定
[出典] "CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells" Krishnamurthy S [..] Saeij JP. mBio 2023-03-14. https://doi.org/10.1128/mbio.00060-23 [著者所属] UC Davis, U Grenoble Alpes トキ ...
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高忠実度Cas9エディターのオンターゲット活性を、Cas9の合理的設計とランダム変異導入によって改善
[出典] "Improving the on-target activity of high-fidelity Cas9 editors by combining rational design and random mutagenesis" Spasskaya DS [..] Karpov DS. Appl Microbiol Biotechnol. 2023-03-14. https://doi.org/10.1007/s00253-023-12469-5 [著者所属] Engelhard ...
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CRISPR-dCas9技術に分割型ルシフェラーゼの組み合わせて、暗中の感染を光らせる
[出典] "Glow-in-the-Dark Infectious Disease Diagnostics Using CRISPR-Cas9-Based Split Luciferase Complementation" van der Veer H [..] Merkx M. ACS Cent Sci. 2023-03-15. https://doi.org/10.1021/acscentsci.2c01467 [著者所属] Eindhoven University of Technolo ...
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GWAS由来の冠動脈疾患関連遺伝子座を標的とするマルチモーダルなCRISPR摂動を加えた結果
- CRISPR KO, CRISPRiおよびCRISPRa[注] 冠動脈疾患(coronary artery disease:CAD)[出典] "Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells" Wünnemann F [..] Lettre G. PLoS Genetics 2023-03-1 ...
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