blogging about crisp bio-S&T, especially CRISPR.

カテゴリ: CRISPR

[出典] "CRISPR/Cas-mediated non-viral genome specific targeted CAR T cells achieve high safety and efficacy in relapsed/refractory B-cell non-Hodgkin lymphoma" Zhang J, Hu Y, Yang J [..] Du B, Liu M, Hang H. Research Square. 2021-04-03 [プレプリント]. htt ... もっと読む

[出典] "An exonuclease protection and CRISPR/Cas12a integrated biosensor for the turn-on detection of transcription factors in cancer cells" Li B, Shao Z, Chen Y. Analytica Chimica Acta. 2021-04-04. 南京医科大学 ... もっと読む

[出典] "Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos" Wei Y [..] Zuo E, Sun Y, Yang H, Zhou C. Protein Cell. 2021-04-01. 自然発生SNPsの影響を ... もっと読む

[出典] "Systemic delivery of CRISPR/Cas9 to hepatic tumors for cancer treatment using altered tropism of lentiviral vector" Lee S, Kim Y-Y, Ahn HJ. Biomaterials. 2021-04-01.; Graphical Abstract https://ar ... もっと読む

[出典] "CRISPR Co-Editing Strategy for Scarless Homology-Directed Genome Editing" Reuven N, Adler J, Myers N, Shaul Y. Int J Mol Sci. 2021-04-03. HDR (相同組み換え修復)を介した遺伝子編集は精密であるが効率が極めて低い ... もっと読む