[出典] "High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA" Oh SA, Senger K, Madireddi S [..] Haley B, Rutz S. J Exp Med. 2022-04-22. https://doi.org/10.1084/jem.20211530[著者所属] Genentech CAR T細胞の作 ...
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カテゴリ: CRISPR
[レビュー] RNA工学の新たな分子ハサミCas13d
[出典] REVIEW "Cas13d: A New Molecular Scissor for Transcriptome Engineering" Gupta R [..] Ghosh D. Front Cell Dev Biol 2022-03-31. https://doi.org/10.3389/fcell.2022.866800 CSIR-Indian Institute of Chemical BiologyとNational Institute of Pharmaceutical ...
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機械学習とコンビナトリアル変異誘発の融合により,スクリーニングの必要性を抑制しつつ,Cas9ゲノムエディターの性能向上を実現
[出典] "Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities" Thean DGL, Chu HY [..] Wong ASL. Nat Commun 2022-04-25. https://doi.org/10.1038/s41467-022-29874-5[著者所属] The Uni ...
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[展望] CRISPR特許係争に対するPTABの裁定について - 特許における「着想」と「発明」の意味
[出典] PERSPECTIVE "Immaculate Conception? Priority and Invention in the CRISPR Patent Dispute" Sherkow JS. CRISPR J. 2022-04-19. https://doi.org/10.1089/crispr.2022.0033[著者所属] Carle Illinois College of Medicine, and Affiliate, Carl R. Woese Institute ...
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産業酵母Yarrowia lipolyticaにおいてCRISPRベースの遺伝子発現ツールキットの挿入に最適なサイトを同定
[出典] "Identification of genome integration sites for developing a CRISPR-based gene expression toolkit in Yarrowia lipolytica " Liu X, Cui Z, Su T, Lu X, Hou J, Qi Q. Microb Biotechnol 2022-04-18. https://doi.org/10.1111/1751-7915.14060[著者所属] 山東 ...
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