[出典] "Breakthrough in Dicot Prime Editing: Enabling Heritable Desired Edits in Tomato and Arabidopsis" Vu TV, Nguyen NT [..] Kim JY. bioRxiv. 2024-02-11 (preprint). https://doi.org/10.1101/2024.02.11.579803 [所属] Gyeongsang National U, Nulla Bio Inc ...
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タグ:塩基エディター
綿花植物 (Gossypium hirsutum, Gh) の塩基編集に最適なエディター
[出典] "Precise fine-turning of GhTFL1 by base editing tools defines ideal cotton plant architecture" Wang G [..] Nie X, Zhang X, Jin S. Genome Biol. 2024-02-26. https://doi.org/10.1186/s13059-024-03189-8 [所属] Huazhong Agricultural U, Shihezi U. これ ...
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塩基編集 (BEs)の結果予測の精度を, 内因性因子のデータを取り入れた深層学習モデルによって改善
[出典] "Deep learning models incorporating endogenous factors beyond DNA sequences improve the prediction accuracy of base editing outcomes" Yuan T, Wu L, Li S, Zheng J, Li N, Xiao X [..] Wei W, Sun Y, Zuo E. Cell Discov. 2024-02-20. https://doi.org/10. ...
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CRISPR塩基編集によるDMD機能喪失変異ヒト胚性幹細胞株の作製
[出典] "Generation of a DMD loss-of-function mutant human embryonic stem cell lines by CRISPR base editing" Jin H [..] Zheng H, Jiang Y. Stem Cell Res. 2024-02-19. https://doi.org/10.1016/j.scr.2024.103343 [所属] Jiaozuo People's Hospital, The Second Affi ...
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ファージ支援指向性進化法を介して、高活性・高選択性・低配列嗜好性のCBEを実現
[注] ファージ支援指向性進化法:PACE (phage-assisted continuous evolution) とPANCE (phage-assisted non-continuous evolution) [出典] "Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context pre ...
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