crisp_bio

blogging about crisp bio-S&T, especially CRISPR.

タグ:エピゲノム編集

1. CRISPR–sciATA (CRISPR-based, single-cell combinatorial indexing assay for transposase-accessible chromatin)[出典] "Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens" Liscovitch-Brauer N [..] Sanjana ... もっと読む

[出典] REVIEW "Reprogramming the anti-tumor immune response via CRISPR genetic and epigenetic editing" Alves E [..] Blancafort P. Mol Ther-Meth Clin D. 2021-04-24 [Journal Pre-proof]. https://doi.org/10.1016/j.omtm.2021.04.009 University of Western Austr ... もっと読む

2021-04-30 Boston Uの研究チームがNuñezらの論文を紹介:一定の遺伝子のサイレンシングを,細胞分裂や分化の過程にわたって確固と維持可能とするプログラム可能なエピジェネティック・メモリー・ライター、CRISPRoff,をdCas9をベースとして開発した;CRISPRoffは,ほとん ... もっと読む

[出典] "A CRISPR/Cas9‐based method for targeted DNA methylation enables cancer initiation in B lymphocytes" Katayama S, Shiraishi  K, Gorai N, Andou M. Adv Genetics. 2021-03-11. https://doi.org/10.1002/ggn2.10040[注] MMEJ: microhomology‐mediated end jo ... もっと読む

[出典] REVIEW "Regulation of Gene Expression and the Elucidative Role of CRISPR-Based Epigenetic Modifiers and CRISPR-Induced Chromosome Conformational Changes" Martella A, Fisher DI. CRISPR J 2021-02-19. https://doi.org/10.1089/crispr.2020.0108  AstraZe ... もっと読む

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