[注] ATAC-see (an assay of transposase-accessible chromatin with visualization) [*][出典] "Genome-wide ATAC-see screening identifies TFDP1 as a modulator of global chromatin accessibility” Ishii S[..] Miyanari Y. Nat Genet 2024-02-15. https://doi.org/10 ...
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タグ:エピゲノム
NLRC5を標的とする脱メチル化と活性化が, MHCクラスIを介したがん免疫原性を増強する
[出典] 論文 "Targeted demethylation and activation of NLRC5 augment cancer immunogenicity through MHC class I" Sun X [..] Kobayashi KS. PNAS. 2023-02-01. https://doi.org/10.1073/pnas.2310821121 [所属] 北大, 東洋大, Texas A&M Health Science Center, ...
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meHOLMES: CRISPR-Cas12aをベースに配列に依存することなくDNAメチル化を迅速検出
[注] HOLMES (an one-HOur Low-cost Multipurpose highly Efficient System) [*][出典] "meHOLMES: A CRISPR-Cas12a-based method for rapid detection of DNA methylation in a sequence-independent manner" Zhuang S, Hu T, Zhou X [..] Pei H, Gu D, Wang J. Heliyo ...
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超小型なエピジェネティックモジュレーターの発見と, CRISPRを介した持続的遺伝子活性化への応用
[出典] "Discovery of hypercompact epigenetic modulators for persistent CRISPR-mediated gene activation" Carosso GA [..] Hart DO. bioRxiv 2024-01-18 (preprint). https://doi.org/10.1101/2023.06.02.543492 [著者所属] Epicrispr Biotechnologies, Stanford U, Ch ...
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O6-メチルグアニン-DNAメチルトランスフェラーゼのメチル化により, テモゾロミドに対する悪性神経膠腫の感受性を亢進
[出典] "dCas9/CRISPR-based methylation of O-6-methylguanine-DNA methyltransferase enhances chemosensitivity to temozolomide in malignant glioma" Rinonos SZ, Li T, Pianka ST [..] Lai A. J Neuro-oncol. 2024-01-15. https://doi.org/10.1007/s11060-023-04531- ...
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